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Rui-Ping Xiao

发布时间:2011-01-04   阅读次数:6467  
Rui-Ping Xiao, M.D. Ph.D
Professor
Directorof IMM/PKU
Principal Investigator, Laboratory of Signal Transduction
 
Room 322, Ying-Jie Conference Center, Yiheyuan Road 5, Haidian District,
Peking University, Beijing, China 100871
E-mail: xiaor@ grc.nia.nih.gov
Phone: 86-10-6275-7243
 
Rui-Ping Xiao was trained as a cardiologist and physiologist at Tong-Ji Medical University in Wuhan, China and the Medical School at University of Maryland at Baltimore (UMAB), where she earned her M.D. in 1984 and Ph.D. in 1995, respectively. She joined the Laboratory of Cardiovascular Science, National Institute of Aging, in 1990 as a postdoctoral fellow, and later in 1996 became a tenure-track investigator and the head of the Receptor Signaling Unit. In 2003, she was converted to Senior Investigator at National Institute of Health, USA. In April 2010, she resigned from NIH and started her career in IMM, Peking University, Beijing, China.
 
Research Interests: Her main scientific focus has been G-protein coupled receptor (GPCR) signaling in the cardiovascular system. Using interdisciplinary approaches, including physiological and pharmacological techniques in conjunction with genetic manipulations (e.g. gene-targeted animal models or adenoviral gene transfer systems), her work revealed dual coupling of b2-adrenergic receptor (b2AR) with two functionally opposite G-protein families, Gs and Gi proteins and its physiological and pathophysiological significance. Ongoing research directions include signaling pathways involved in cardiac myocyte apoptosis, hypertrophy, regeneration, and atherosclerosis. In addition, considerable efforts have been devoted to understanding mechanisms underlying cardiac aging and heart failure and developing novel therapies for the treatment of heart failure.
 
Selected Publications since 2000:
    1. 74. Song RS, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP. Central Role of E3 Ubiquitin Ligase MG53 in Insulin Resistance and Metabolic Disorders. Nature, 2012 (Accepted)
      73. Zhang Y, Zhang T, Cao CM, Xiao RP. mTOR: Good, Bad, or Ugly? Cardiovasc Res, 2012; 10.1093/cvr/cvs201.
      72. Weisleder N, Takizawa N, Lin P, Wang X, Cao CM, Zhang Y, Tan T, Ferrante C, Zhu H, Chen PJ, Yan R, Sterling M, Zhao X, Hwang M, Takeshima M, Cai C, Cheng H, Takeshima H, Xiao RP, Ma J. Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy. Sci Transl Med, 2012; 4: 139ra85.
      71. Zhang, Y., Lv, F.X., Jin, L., Peng, W., Song, R.S., Ma, J., Cao, C.M., Xiao, R.P.: MG53 Participates in Ischemic Postconditioning through the RISK Signaling Pathway. Cardiovascular Res, 2011 Feb 1. [Epub ahead of print].
    2. 70. Zheng, M., Xiao, R.P.: Role of Mitofusin-2 in Cardiovascular Oxidative Stress. J. Mol. Med. 88:987-991, 2010.
    3. 69. Talan, M.I., Ahmet, I., Xiao, R.P., Lakatta, E.G.:b2-AR Agonists in Treatment of Chronic Heart Failure: Long Path to Translation. J Mol. Cell. Cardiol. 2010 Oct1. [Epub ahead of print].
    4. 68. Zhang, Y., Cao, C.M., Xiao, R.P.: Kinase Activity-Independent Anchoring Function of Protein Kinase Cd. Am J Physiol Cell Physiol. 299:C733-735, 2010.
    5. 67. Wang, X., Xie, W., Zhang, Y., Lin, P., Han, L., Han, P., Wang, Y., Chen, Z., Ji, G., Zheng, M., Weisleder, N., Xiao, R.P., Takeshima, H., Ma. J, Cheng, H.: Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res. 107:76-83, 2010.
    6. 66. Cao, C.M., Zhang, Y., Weislede, N., Ferrante, C., Wang, X.H., Lv, F., Zhang, Y., Song, R.S., Hwang, M., Jin, L., Guo, J., Peng, W., Li, G., Nishi, M., Takeshima, H., Ma, J., Xiao, R.P.: MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation. 121: 2565-74, 2010.
    7. 65. Jozwiak, K., Toll, L., Jimenez, L., Woo, A.Y., Xiao, R.P., Wainer, I.W.: The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor. Biochem Pharmacol. 79:1610-5, 2010.
    8. 64. Jozwiak, K., Woo, A.Y.H., Tanga, M.J., Toll, L., Jimenez, L., Kozocas, J.A., Plazinska, A., Xiao, R.P., Wainer, I.W.: Comparative Molecular FieldAnalysis of Fenoterol Derivatives: A Platform Towards Highly Selective and Effective beta2-Adrenergic Receptor Agonists. Bioorganic & Medicinal Chemistry. 18:728-36, 2010.
    9. 63. Li, Q., Li, G., Lan, X., Zheng, M., Chen, K.H., Cao, C., Xiao, R.P.: Receptor Interacting Protein 3 Suppresses Vascular Smooth Muscle Cell Growth by Inhibition of PI3K-Akt Axis. J. Biol. Chem. 285:9535-44, 2010.
    10. 62. Tsang, S., Woo, A.Y.H., Zhu, W., Xiao, R.P.: Deregulation of RGS2 in Cardiovascular Diseases. Frontiers in Bioscience. 2:547-57, 2010.
    11. 61. Ekhterae, D., Hinmon, R., Zeeshan, A., Parish, L., Zhu W., Xiao, R.-P., Gorman, R.C., Gorman, J.H.: Infarction Induced Myocardial Apoptosis and ARC Activation. J Surg Res.. 2010, Jun 6. [Epub ahead of print]
    12. 60. Peng, W., Zhang, Y., Zheng, M., Cheng, H., Zhu, W., Cao, C.M.*, Xiao, R.P.*: Cardioprotection by CaMKII-δB is mediated by phosphorylation of HSF1 and subsequent expression of inducible HSP70. Circulation Research, 2009 Nov 12. [Epub ahead of print].
    13. 59. Ekhterae, D., Hinmon, R., Zeeshan, A., Parish, L., Zhu W., Xiao, R.-P., Gorman, R.C., Gorman, J.H.: Infarction Induced Myocardial Apoptosis and ARC Activation.Journal of Thoracic and Cardiovascular Surgery. 2009, Jun 6. [Epub ahead of print].
    14. 58. Peng, W., Zhang, Y., Zhu, W., Cao, C.M., Xiao, R.P.: AMPK and TNF-a at the Crossroad of Cell Survival and Death in Ischemic Heart. Cardiovasc Res. 2009, 84(1):1-3.
    15. 57. Chakir, K., Daya, S., Tunin, R.S., Liang, H.Y., Abraham, T., Lai, E. W., Pacak, K., Xiao, R.P., Tomaselli, G. F., Kass, D. A.: Mechanisms of Enhanced Beta-adrenergic Reserve From Cardiac Resynchronization Therapy. Circulation. 2009, 119:1231-40.
    16. 56. Pang, J., Zeng, X., Xiao, R.P., Lakatta, E.G., Lin, L.: Design, generation, and testing of mammalian expression modules that tag membrane proteins. Protein Sci. 2009; 18:1261-71
    17. 55. Lee, D.I., Klein, M.G., Zhu, W., Xiao, R.P., Gerzanich, V., Xu, K.Y.: Activation of (Na++K+)-ATPase Modulates Cardiac L-Type Ca2+ Channel Function. Mol Pharmacol. 2009, 75:774-81.
    18. 54. Woo, A.Y.H., Wang, T.B., Zhu, W., Abernethy, D., Wainer, I., Xiao, R.P.: Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. Mol. Pharmacol. 2009;75:158-65.
    19. 53. Ahmet, I., Krawczyk, M., Zhu, W., Woo, A., Morrell, C., Poosala, S., Xiao, R.P., Lakatta, E.G., Talan, M.: Cardioprotective and survival benefits of long-term combined therapy with β2AR Agonist and β1AR Blocker in dilated cardiomyopathy post-myocardial infarction. JPET. 325:491-9, 2008.
    20. 52. Luo, D., Yang, D., Lan, X., Li, K., Li, K., Chen, J., Zhang, Y., Xiao, R.P., Han, Q., and Cheng, H.: Perinuclear Ca2+ Waves in developing cardiac myocytes:Inositol 1,4,5-trisphosphate receptor regulation of nuclear Ca2+ signaling Cell. Calcium. 43:165-74, 2008.
    21. 51. Guo, X., Chen K.H., Li, Q., Liao, H., Zhang, J., Tang, J., and Xiao, R.P. Mitofusin-2 induces vascular smooth muscle apoptosis via mitochondrial death pathway. Circ. Res. 101:1113-22, 2007.
    22. 50. Shen, T, Zheng, M., Cao, C., Chen, L., Zhang, W., Cheng, H., Tong, J., Chen, K.H., and Xiao, R.P.: Mitofusin-2 is a major determinant of oxidative stress-mediated heart muscle cell apoptosis. J. Biol. Chem. 282:23354-23361,2007.
    23. 49. Jozwiak K., Khalid C., Tanga M.J., Berzetei-Gurske I., Jimenez L., Kozocas J.A., Woo A., Zhu W., Xiao, R.P., Abernethy D.R., Wainer I.W. Comparative Molecular Field Analysis (CoMFA) of the Binding of the Stereoisomers of Fenoterol and Fenoterol Derivatives to the beta2 Adrenergic Receptor. J. Med. Chem. 2007, 50:2903-2915, 2007.
    24. 48. Zhu, W.Z., Woo, A. Y.-H., Yang, D., Cheng, H., Crow, M.T., Xiao, R.P. Activation of CaMKIIdc is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis. J Biol Chem, 282:10833-10839, 2007.
    25. 47. Yang, D., Zhu, W.Z., Xiao, B., Brochet, D., Chen, W., Lakatta, E.G.,, Xiao, R.P., Cheng, H. Ca2+/Calmodulin kinase II -dependent phosphorylation of ryanodine receptors suppresses spontaneous Ca2+ release in cardiac myocytes, Circ Res. 2007, 100:399-40.
    26. 46. Vinogradova, T.M., Lyashkov, A.E., Zhu, W., Ruknudin, A.M., Sirenko, S., Yang, D., Deo, S., Barlow, M., Johnson, S., Caffrey, J.L., Zhou, Y.Y., Xiao, R.P., Cheng, H., Stern, M.D., Maltsev, V.A. and Lakatta, E.G..: High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ. Res. 98:505-514, 2006.
    27. 45. Yang, Y., Zhu, W.Z., Joiner, M.L., Zhang, R., Oddis, C.V., Hou, Y., Yang, J., Price, E.E., Gleaves, L., Eren, M., Ni, G., Vaughan, D.E., Xiao, R.P., Anderson, M.E. Calmodulin Kinase II inhibition protects against myocardial apoptosis in vivo by phospholamban-dependent and –independent mechanisms. Am J Physiol Heart Circ Physiol. 2006,291:H3065-75.
    28. 44. Beigi, F., Bertucci, C., Zhu, W., Chakir, K., Wainer, I.W., Xiao, R.P., Abernethy, D.R. Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality. 2006, 18:822-7.
    29. 43. Xiao, R.P., Zhu, W.Z., Zheng, M., Cao, C.M., Zhang, Y.Y., Lakatta, E.G., Han ,Q,D.: Subtype-specific alpha1- and beta-adrenoceptor signaling in the heart. Trends Pharmacol Sci. 27: 330-337, 2006 (Invited review).
    30. 42. Zhu, W., Zeng, X., Zheng M, Xiao, R.P.: The enigma of cardiac beta2-adrenergic Gi signaling in the heart: the good, the bad, and the ugly. Circ. Res. 97: 507-509, 2005 (Commentary).
    31. 41. Zheng, M., Zhu, W., Han, Q., Xiao, R.P.: Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling. Pharmacol. Ther. 108: 257-68, 2005 (Invited Review).
    32. 40. Zhu, W.Z., Yang, D., Zhang, S.J., Chakir, K., Cheng, H., Lavoie, C., Mercier, J.F., Bouvier, M., Hébert, T.E., Lakatta, E.G., Xiao, R.P.: Dimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility. Circ. Res. 97: 244-251, 2005.
    33. 39. Luo, D., Sun, H., Xiao, R.P., & Han, Q. Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells. Eur. J. Pharmacol., 509: 109-115, 2005.
    34. 38. Xu, X., Yang, D., Ding, J., Wang, W., Chu, P.H., Dalton, N.D., Wang, H.Y., Bermingham, J.R. Jr., Ye, Z., Liu, F., Rosenfeld, F.G., Manley, J.L., Ross, J. Jr., Chen, J., Xiao, R.P., Cheng H., and Fu, X.D. ASF/SF2-regulated postnatal reprogramming of CaMKIId alternative splicing modulates excitation-contraction coupling in cardiac muscle. Cell. 120: 59-72, 2005.
    35. 37. Zheng, M., Jo, S.H., Wersto, R., Han, Q., and Xiao, R.P.: Intracellular acidosis-induced p38 MAPK activation and its pathophysiological relevance in cardiomyocyte ischemia. FASEB J. 19: 109-111, 2005.
    36. 36. Wang, W., Zhu, W., Wang, S., Yang, D., Crow, M.T., Xiao, R.P., Cheng, H.: Sustained b1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ. Res. 95: 798-806, 2004.
    37. 35. Leblais, V., Jo, S.H., Chakir, K., Maltsev, V., Zheng, M., Crow, M.T., Wang, W., Lakatta, E.G., and Xiao, R.P.: Phosphatidylinositol 3-kinase offsets camp-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes. Circ. Res. 95: 1183-1190, 2004.
    38. 34. Beigi, F., Chakir, K., Xiao, R.P., and Wainer, I.W.: G-protein-coupled receptor chromatographic stationary phases ii: ligand-induced conformational mobility on an immobilized beta2-adrenergic receptor. Anal. Chem. 76: 7187-7193, 2004.
    39. 33. Zheng, M., Hou, R., Han, Q., and Xiao, R.P.: Different regulation of erk1/2 activation by beta-adrenergic receptor subtypes in adult mouse cardiomyocytes. Heart, Lung & Circulation. 13: 179-184, 2004.
    40. 32. Zheng, M., Hou, R., and Xiao, R.P.: Acidosis-induced p38 MAPK activation and its implication in regulation of cardiac contractility. Acta Pharmacol Sin. 25: 1299-1305, 2004.
    41. 31. Chen, K.H., Guo, X.M., Ma, D.L., Guo, Y.H., Li, Q., Li, P., Qiu, X., Xiao*, R.P., and Tang, J.: Dysregulation of a novel hyperplasia suppressor gene triggers vascular proliferative disorders. Nature Cell Biology, 6: 872-883, 2004 (* The corresponding author).
    42. 30. Pepe, S., van den Brink, O.W.V., Lakatta, E.G., and Xiao, R.P.: beta-adrenergic receptor-opioid peptide receptor cross-talk: cardiovascular regulation and adaptation in health and disease. Cardiovascular Research. 15;63:414-22, 2004 (Invited review).
    43. 29. Xiao, R.P., Zhu, W., Zheng, M., Bond, R., Lakatta, E.G., and Cheng, H.: Subtype-specific beta-adrenergic signaling pathways and their clinical implications. Trends Pharmacol Sci. 25: 358-365, 2004 (Invited review)
    44. 28. Patterson, A.J., Zhu, W., Chow, A., Kosek, J., Xiao, R.P., and Kobilka, B.K.: Protecting the myocardium: A role for the beta2-Adrenergic receptor in the heart. Critical Care Medicine. 32: 1041-1048, 2004.
    45. 27. Ding, J.H., Xu, X., Yang, D., Chu, P.H., Dalton, N.D., Ye, Z., Yeakley, J.M., Cheng, H., Xiao, R.P., Ross, J., Chen, J., and Fu, X.D.: Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J. 23: 885-896, 2004.
    46. 26. Xiao, R.P., and Balke, C,W,: Na+/Ca2+ Exchange Linking beta2-Adrenergic Gi Signaling to Heart Failure: Associated Defect of Adrenergic Contractile Support. J Mol. Cell. Cardiol. 36: 7-11, 2004 (Editorial).
    47. 25. Chu, G., Egnaczyk, G.F., Zhao, W., Jo, S.H., Fan, G.C., Maggio, J.E., Xiao, R.P., and Kranias, E.G.: Phosphoproteome Analysis of Cardiomyocytes Subjected to beta-Adrenergic Stimulation: Identification and Characterization of a Novel Heat Shock Protein. Circ. Res. 94: 184-193, 2004.
    48. 24. Xiao, R.P., Cheng, H., Zhoum Z., Chenm Y., Wum C. and Gum X.C.: Is china ready to go mainstream in molecular medicine China Voices II (Supplement to nature). 432: A42-A45, 2004.
    49. 23. Cheng, A., Wang, S., Yang, D., Xiao, R.P., and Mattson, M.: Calmodulin mediates BDNF cell survival signaling upstream of Akt kinase in embryonic neocortical neurons. J. Biol. Chem. 278: 7591-7599, 2003.
    50. 22. Zhu, W.Z., Wang, S.Q., Chakir, K., Kolbilka, B.K., Cheng, H., and Xiao, R.P.: Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/Calmodulin Kinase II. J. Clin. Invest. 111: 617-625, 2003.
    51. 21. Sasaki, N., Murata, M., Guo, Y., Jo, S.H., Ohler, A., Akao, M., O'Rourke, B., Xiao, R.P., Bolli, R., and Marban, E.: MCC-134, a single pharmacolphore, opens surface adenosine triphosphate-sensitive potassium channels, blocks mitochondrial adenosine triphosphate-sensitive potassium channels, and suppresses preconditioning. Circulation. 107: 1183-1188, 2003.
    52. 20. Yang, D., Zhu, W.Z., Chakir, K., Wang, W., Wu, C., Wang, Y., Xiao, R.P., Chen, W.S., and Cheng, H.: calmodulin regulation of excitation-contraction coupling in cardiac myocytes. Circ. Res. 92: 659-667, 2003.
    53. 19. Chakir, K., Xiang, Y., Zhang, S.J., Yang, D., Cheng, H., Kobilka, B.K., and Xiao, R.P.: The third intracellular loop and the carboxyl terminus of beta2-adrenergic receptor confer the receptor spontaneous activity. Mol. Pharmacol. 64: 1048-1058, 2003.
    54. 18. Xiao, R.P., Zhang, S.J. Kuschel, M., Zhou, Y.Y., Bond, R.A., Balke, C.W., Lakatta, E.G., and Cheng, H.: Enhanced Gi signaling mediates the diminution of beta2-adrenergic contractile response in failing spontaneous hypertensive rat heart. Circulation. 108:1633-1639, 2003.
    55. 17. Song, L.S., Guia, A., Muth, J.N., Wang, S.Q., Xiao, R.P., Josephson, I.R., Schwartz, A., Lakatta, E.G., and Cheng, H.: Ca2+ signaling in hypertrophic transgenic cardiac myocytes overexpressing the α1 subunit of L-type Ca2+ channel. Circ. Res. 90: 174-181, 2002.
    56. 16. Liao, P., Wang, S.Q., Zheng, M., Zheng, M.Z., Cheng, H., Wang, Y., and Xiao, R.P.: p38 mitogen activated protein kinase mediates negative inotropic effect in cardiac myocytes. Circ. Res. 90: 190-196, 2002.
    57. 15. Hagemann, D., and Xiao, R.P.: Dual site phospholamban phosphorylation and its physiological relevance in the heart. Trends Cardiovasc Med. 12: 51-56, 2002 (Invited review).
    58. 58. Jo, S.H., Leblais, V., Crow, M.T., and Xiao, R.P.: Phosphatidylinositol 3-kinase functionally compartmentalizes the concurrent Gs signaling during beta2-adrenergic stimulation. Circ. Res. 91: 46-53, 2002.
    59. 14. Lavoie, C., Mercier, J.F., Salahpour, A., Umapathy, D., Breit, A., Villeneuve, L.R., Zhu, W.Z., Xiao, R.P., Lakatta, E.G., Bouvier, M., and Hébert, T.E.: beta1/beta2-adrenergic receptor heterodimerization regulates beta2-adrenergic receptor internalization and ERK signaling efficacy. J. Biol. Chem. 277: 35402-35410, 2002.
    60. 13. Zhu, W.Z., Zheng, M., Lefkowitz, R.J., Koch, W.J., Kobilka, B., and Xiao, R.P.: Dual modulation of cardiac cell survival and cell death by beta2-adrenergic signaling in adult mouse heart cells. Proc. Nat. Acad., Sci. USA 98: 1607-1612, 2001.
    61. 12. Song, L.S., Wang, S.Q., Xiao, R.P., Spurgeon, H., Lakatta, E.G., and Cheng, H.: beta-adrenergic stimulation synchronizes intracellular Ca2+ release during excitation-contraction coupling in cardiac myocytes. Circ. Res. 88: 794-801, 2001.
    62. 11. Liao, P., Georgakopoulos, D., Kovacs, A., Zheng, M., Lerner, D., Pu, H., Saffitz, J., Chien, K., Xiao, R.P., Kass, D.A. and Wang, Y.: The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc. Nat. Acad., Sci. USA 98: 12283-12288, 2001.
    63. 10. Xiao, R.P.: β-adrenergic signaling in the heart: Dual coupling of the β2-adrenergic receptor to Gs and Gi proteins. Science's STKE. 16: RE15, 2001 (Invited review).
    64. 9. Zhang, S.J., Cheng, H., Zhou Y.Y., Wang, D.J., Zhu, W., Ziman, B., Spurgeon, H., Lefkowitz, R.J., Lakatta, E.G., Koch, W.J., and Xiao, R.P.: Inhibition of spontaneous beta2-adrenergic activation rescues beta1-adrenergic contractile response in cardiomyocytes overexpressing beta2-adrenoceptor. J. Biol. Chem. 275: 21773-21779, 2000.
    65. 8. Hagemann, D., Kuschel, M., Kuromochi, T., Zhu, W., Cheng, H., and Xiao, R.P.: Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. J. Biol. Chem. 275: 22532-22536, 2000.
    66. 7. Zhou, Y.Y., Wang, S.Q., Zhu, W., Chruscinski, A., Kobilka, B., Ziman, B., Wang, S., Lakatta, E.G., Cheng, H., and Xiao, R.P.: High efficient adenovirus-directed gene transfer in cultured adult mouse ventricular myocytes. Am. J. Physiol. 279: H429-H436, 2000.
    67. 6. Vinogradova, T.M., Zhou, Y.Y., Bogdanov, K.Y., Kuschel, M., Cheng, H., and Xiao, R.P.: Sinoatrial node pacemaker activity requires Ca2+/calmodulin-dependent protein kinase II activation. Circ. Res. 87: 760-767, 2000.
    68. 5. Xiao, R.P.: Cell logic for dual coupling of a single class of receptors to Gs and Gi proteins. Cric. Res. 87: 635-637, 2000 (Editorial).
    69. 4. Zhou, Y.Y., Zhu, W., Zhang, S..J., Wang, D.J., Kobilka, B., Lakatta, E.G., Cheng, H., and Xiao, R.P.: Ligand-independent activation of beta2- but not b1-adrenoceptor overexpressed in beta1/beta2-adrenoceptor double knockout mouse cardiomyocytes. Mol. Pharmacol. 58: 887-894, 2000.
    70. 3. Chen, Y., Xiao*, R.P. Izu, L.T., Cheng, H., Kuschel, M., Spurgeon, H., and Lakatta, E.G.: Gi-dependent localization of beta2-adrenergic receptro signaling to L-type Ca2+ channels. Biophys. J. 79: 2547-2556, 2000 (* The corresponding author).
    71. 2. Chesley, A., Ohtani, S., Asai, T., Xiao, R.P., Lunberg, M.S., Lakatta, E.G., and Crow M.T.: beta2-adrenergic receptor delivers an anti-apoptotic signal to cardiac myocytes through Gi-dependent signaling pathways. Circ. Res. 87: 1172-1179, 2000.
    72. 1. Zheng, M., Zhang, S.J., Zhu, W., Ziman, B., Kobilka, B.K., and Xiao, R.P.: beta2-adrenergic receptor-induced p38 MAPK activation is mediated by PKA rather than by Gi or Gb in adult mouse cardiomyocytes. J. Biol. Chem. 275: 40635-40640, 2000.
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