陈雷 研究员 阅读次数:

陈雷 研究员
 

Ph.D. , 博士生导师

结构生物学实验室主任

北大清华生命科学联合中心研究员

 

E-mail: chenlei2016@pku.edu.cn

通讯地址:北京大学王克桢楼218室 100871

 

2001-2005就读于清华大学生物科学与技术系,获理学学士学位;2005-2010年就读于清华大学生命科学学院,获理学博士学位。2010-2016在美国俄勒冈健康与科学大学沃勒姆研究所从事博士后研究,于2016年任北京大学分子医学研究所结构生物学研究室主任,北大清华生命科学联合中心研究员。

早年从事AMPK调控分子机制的研究,博士后期间从事AMPA受体激活机制的研究。目前实验室主要致力于以结构生物学手段为主、生物化学和电生理手段为辅研究细胞膜整合蛋白的工作机制。

 

代表论文

1. Guo W., Chen L. [Review] Recent progress in structural studies on canonical TRP ion channels. Cell Calcium (2019), 83, 102075.

2. Wu J. X., Ding D., Wang M., Chen L. [Review] Structural Insights into the Inhibitory Mechanism of Insulin Secretagogues on the Pancreatic ATP-Sensitive Potassium Channel. Biochemistry (2019).

3. Kang Y.*, Liu R.*, Wu J. X.,Chen L. Structural insights into the mechanism of human soluble guanylate cyclase. Nature (2019), 574, 206-210.

4. Ding, D., Wang, M., Wu, J.X., Kang, Y., and Chen, L. (2019). The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel. Cell Rep 27, 1848-1857 e1844.

5. Zhang, M., Wang, D., Kang, Y., Wu, J.X., Yao, F., Pan, C., Yan, Z.#, Song, C.#, and Chen, L.# (2018). Structure of the mechanosensitive OSCA channels. Nature structural & molecular biology 25, 850-858.

6. Tang, Q.*, Guo, W.*, Zheng, L., Wu, J.X., Liu, M., Zhou, X., Zhang, X.#, and Chen, L.# (2018). Structure of the receptor-activated human TRPC6 and TRPC3 ion channels. Cell research.

7. Wu, J.X., Ding, D., Wang, M., Kang, Y., Zeng, X., and Chen, L. (2018). Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell 9, 553-567.

8. Li, N.*, Wu, J.X.*, Ding, D., Cheng, J., Gao, N.#, and Chen, L#. (2017). Structure of a Pancreatic ATP-Sensitive Potassium Channel. Cell 168, 101-110 e110.(# Co-corresponding author)

9. Chen, L., Dürr, KL., Gouaux, E. (2014). X-ray structures of AMPA receptor–cone snail toxin complexes illuminate activation mechanism. Science 345, 1021-1026

10. Dürr, KL.*, Chen, L.*, Stein, RA., De Zorzi, R., Folea, IM., Walz, T., Mchaourab, HS., Gouaux, E. (2014). Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States. Cell 158,  778–792  (*Co-first author)

11. Chen, L., Xin, F.J., Wang, J., Hu, J., Zhang, Y.Y., Wan, S., Cao, L.S., Lu, C., Li, P., Yan, S.F., et al. (2013). Conserved regulatory elements in AMPK. Nature 498, E8-10.

12. Chen, L., Wang, J., Zhang, Y.Y., Yan, S.F., Neumann, D., Schlattner, U., Wang, Z.X., and Wu, J.W. (2012). AMP-activated protein kinase undergoes nucleotide-dependent conformational changes. Nat Struct Mol Biol 19, 716-718.

13. Liu, Y.T., Dan, Q.J., Wang, J., Feng, Y., Chen, L., Liang, J., Li, Q., Lin, S.C., Wang, Z.X., and Wu, J.W. (2011). Molecular basis of Wnt activation via the DIX domain protein Ccd1. J Biol Chem 286, 8597-8608.

14. Wang, L., Liu, Y.T., Hao, R., Chen, L., Chang, Z., Wang, H.R., Wang, Z.X., and Wu, J.W. (2011). Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem 286, 15883-15894.

15. Zhu, L., Chen, L., Zhou, X.M., Zhang, Y.Y., Zhang, Y.J., Zhao, J., Ji, S.R., Wu, J.W., and Wu, Y. (2011). Structural insights into the architecture and allostery of full-length AMP-activated protein kinase. Structure 19, 515-522.

16. Chen, L.,* Jiao, Z.H.*, Zheng, L.S.*, Zhang, Y.Y., Xie, S.T., Wang, Z.X., and Wu, J.W. (2009). Structural insight into the autoinhibition mechanism of AMP-activated protein kinase. Nature 459, 1146-1149. (*Co-first author).

17. Wang, C., Chen, L., Wang, L., Wu, J.W. (2009). Crystal structure of the MH2 domain of Drosophila Mad. Sci China C Life Sci. 52(6):539-44.

18. Hao, R., Chen, L., Wu, J.W., and Wang, Z.X. (2008). Structure of Drosophila Mad MH2 domain. Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 986-990.