胡新立 副研究员 阅读次数:

胡新立 博士

副研究员

转基因和基因敲除小鼠平台Co-PI

E-mail: huxxx025@pku.edu.cn

通讯地址:北京大学英杰交流中心100871



 

1987-1991年就读于北京大学生物系细胞遗传专业,获理学学士学位。1991年进入北京大学生物系细胞专业读研究生,1996年获得博士学位。随后在美国明尼苏达大学药理系做博士后,主要研究细胞核受体及其它转录调控因子在调节基因表达和染色质结构方面的作用。2005年,转入明尼苏达大学医学系心血管研究所,把分子生物学的研究方法应用于心血管疾病病理的研究,将转基因动物模型与分子生物学手段相结合,研究在心肌肥厚和心衰过程中KATP离子通道和AMPK激酶参与调节心肌能量代谢有关的基因表达的分子机制。同时,建立了可诱导基因敲除小鼠系,用于研究一氧化氮信号通路在心血管系统中的作用。2011年中回国,负责北京大学分子医学所转基因和基因敲除小鼠平台的筹备和运作。

胡新立博士先后在Circulation, Circulation Research, Journal of Biological Chemistry 等杂志上发表论文四十余篇。其中利用基因敲除小鼠研究一氧化氮分子信号通路的研究工作获得美国心脏协会2008年年会Young Investigator Travel Award,并入选 2010年年会的AHA Best of Specialty Conferences Poster Session.

代表论文:

12. Liu F, Song R, Feng Y, Guo J, Chen Y, Zhang Y, Chen T, Wang Y, Huang Y, Li CY, Cao C, Zhang Y, Hu X*, Xiao RP*. Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor α. Circulation, 131(9):795-804, 2015.

11. Wang H, Xu X, Fassett J, Kwak D, Liu X, Hu X, Falls TJ, Bell JC, Li H, Bitterman P, Bache RJ, Chen Y. Double-stranded RNA–dependent protein kinase deficiency protects the heart from systolic overload-induced congestive heart failure. Circulation, 129(13): 1397-1406, 2014.

10. Hu X*, Chang N, Wang X, Zhou F, Zhou X, Zhu X, Xiong JW*. Heritable gene-targeting with gRNA/Cas9 in rats. Cell Research. 23(11):1322-5, 2013.

9. Hu XL, Zhang P, Xu X, Lu Z, Zhu G, Fassett J, Viollet B, Zhuo M, Tao Y, Chen Y.AMPK?2 regulates expression of ERR?, a metabolic transcription factor related to heart failure development. Hypertension, 58(4): 696-703. 2011

8. Hu XL, Atzler D, Xu X, Zhang P, Guo H, Lu Z, Fassett J, Schwedhelm E, B?ger RH, Bache RJ, Chen Y. Global Dimethylarginine Dimethylaminohydrolase-1 (DDAH1) Gene-Deficient Mice Reveal That DDAH1 Is the Critical Enzyme for Degrading the Cardiovascular Risk Factor Asymmetrical Dimethylarginine. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(7): 1540-1546. 2011

7. Hu XL, Xu X, Zhu G, Atzler D, Kimoto M; Chen J; Schwedhelm E, Lüneburg N; B?ger RH, Zhang P, Chen Y. Vascular endothelial specific DDAH1 gene deficient mice reveal vascular endothelium as the primary site to remove toxic methylarginines. Circulation, 120: 2222 – 2229. 2009

6. Xu X*, Hu X*, Lu Z, Zhang P, Zhao L, Wessale JL, Bache RJ, Chen Y. Xanthine oxidase inhibition with Febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. Journal of Cardiac Failure. 2008; 14(9):746-753.

5. Hu X, Xu X, Huang Y, Fassett J, Flagg TP, Zhang Y, Nichols CG, Bache RJ, Chen Y. Disruption of Sarcolemmal ATP-Sensitive Potassium Channel Activity Impairs the Cardiac Response to Systolic Overload. Circulation Research. 103(9):1009-17. 2008

4. Hu XL, Chen YX, Farooqui M, Chiang CM, Wu SH, Wei LN, Ligand-dependent, negative modulation of retinoic acid-induced transcriptional activation by antagonism of receptor interacting protein 140 (RIP 140) toward p300/CBP-associated factor P/CAF. Journal of Biological Chemistry, Vol. 279(1): 51-60, 2004

3. Hu XL, Bi J, Loh H, Wei LN, Regulation of Mouse Opioid Receptor Gene Expression by Different 3'-Untranslated Regions and the Effect of Retinoic Acid. Molecular Pharmacology, Vol. 62: 881 – 887, 2002

2. Hu XL, Bi J, Loh H, Wei LN, An intronic Ikaros-binding element mediates retinoic acid suppression of Kappa opioid receptor gene, accompanied by recruiting histone deacetylases. Journal of Biological Chemistry, Vol. 276(7): 4597-4603, 2001

1. Hu XL, Cao S, Loh H, and Wei, LN, Promoter activity of mouse k opioid receptor gene in transgenic mouse. Molecular Brain Research, 69(1): 35-43, 1999