邱义福 研究员 阅读次数:

邱义福 研究员

Ph.D. , 博士生导师

免疫与代谢研究室主任

北大清华生命科学联合中心研究员 

E-mail: yifu.qiu@pku.edu.cn

通讯地址:北京大学王克桢楼221室 100871

 

2000年毕业于南昌大学生物工程专业,获理学学士学位。2010年于中科院上海生命科学研究院获得博士学位。2010-2015年在加州大学旧金山分校进行博士后研究。2015年11月任北京大学分子医学研究所研究员,同时加入北大-清华生命科学联合中心。2016年入选第七批“青年千人计划”。

邱义福实验室主要研究代谢和免疫系统的交互作用,目前专注于能量代谢的免疫学调控机制。炎症反应是许多重大慢性代谢疾病的普遍特征,包括肥胖、2型糖尿病、血脂紊乱及心血管疾病,然而免疫系统如何在组织和动物整体水平上调控代谢系统,仍然很不清楚。他的研究揭示,寒冷刺激除了激活经典的交感神经系统,还激活替代性活化巨噬细胞,进而作为儿茶酚胺的第二细胞来源,参与调控白色脂肪和褐色脂肪中的肾上腺素信号通路及适应性产热(Nature 2011)。他还进一步发现,以2型免疫系统和巨噬细胞为代表的先天免疫系统,在白色脂肪褐化中发挥关键作用(Cell 2014)。这些发现挑战了多年来的教条——神经内分泌系统介导所有对低温环境及饮食的适应性反应,受到国际同行和媒体的广泛引用和报道。

 

代表论文

I. 第一或者共同第一作者论文

3. Yifu Qiu, Khoa D. Nguyen, Justin I. Odegaard, Xiaojin Cui, Xiaoyu Tian, Richard M. Locksley, Richard D. Palmiter, Ajay Chawla. Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat. Cell, 157, 1292–1308 (2014).

Featured in Previews, Cell, 157, 1249-50 (2014); Research Highlight, Nature Reviews Immunology,14, 433 (2014); Research Highlights, Nature Medicine, 20, 714 (2014); News & Opinion, The Scientist, Jun. 5, 2014.

2. Khoa D. Nguyen*, Yifu Qiu*, Xiaojin Cui, Y. P. Sharon Goh, Julia Mwangi, Tovo David, Lata Mukundan, Frank Brombacher, Richard M. Locksley & Ajay Chawla. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature, 480, 104-108 (2011). (*equal contribution).

Featured in News & Views, Nature, 480, 46-47 (2011); Select, Cell, 147, 1427 (2011); Editor’s choice in immunology, The Scientist, Feb. 1, 2012.

1. Yifu Qiu, Ting Mao, Yongliang Zhang, Mengle Shao, Jia You, Qiurong Ding, Yan Chen, Dongmei Wu, Dong Xie, Xu Lin, Xiang Gao, Randal J. Kaufman, Wenjun Li, Yong Liu. A crucial role for RACK1 in regulation of glucose-stimulated IRE1alpha activation in pancreatic beta-cells. Science Signaling 3, ra7 (2010).

Highligted in Perspective, Science Signaling 3, pe7 (2010).

II. 共同署名论文

8. Xiao-Yu Tian, Kirthana Ganeshan, Cynthia Hong, Khoa D. Nguyen, Yifu Qiu, Jason Kim, Rajendra K. Tangirala, Peter Tonotonoz, Ajay Chawla. Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metabolism, 23, 1–14, (2016).

7. Min-Woo Lee, Justin I Odegaard, Lata Mukundan, Yifu Qiu, Ari B Molofsky, Jesse C Nussbaum, Karen Yun, Richard M Locksley, Ajay Chawla. Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis. Cell, 160, 74–87 (2015).

6. Mengle Shao, Bo Shan,Yang Liu, Yiping Deng, Cheng Yan, Ying Wu, Ting Mao, Yifu Qiu, Yubo Zhou, Shan Jiang, Weiping Jia, Jingya Li, Jia Li, Liangyou Rui, Liu Yang and Yong Liu. Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nature Communications, 5:3528 (2014).

5. Amin Khalifeh Soltani, William McKleroy, Stephen Sakuma, Yuk Yin Cheung, Kevin Tharp, Yifu Qiu, Andreas Stahl, Ajay Chawla, and Kamran Atabai. Mfge8 is a central regulator of fatty acid uptake and obesity. Nature Medicine, 20(2):175-83 (2014).

4. Jose Barreto Campello Carvalheira, Yifu Qiu, Ajay Chawla. Blood Spotlight on Leukocytes and Obesity. Blood, 122(19):3263-7 (2013). (review).

3. Khoa D. Nguyen, Sarah J. Fentress, Yifu Qiu, Karen Yun, Jeffery S. Cox, Ajay Chawla. Circadian gene Bmal1 regulates diurnal oscillations to Ly6Chi inflammatory monocytes. Science, 341, 1483-1488 (2013). (Research Article).

2. Ting Mao, Mengle Shao, Yifu Qiu, Jialiang Huang, Yongliang Zhang, Bo Song, Qiong Wang, Lei Jiang, Yi Liu, Jing-Dong J. Han, Pengrong Cao, Jia Li, Xiang Gao, Liangyou Rui, Ling Qi, Wenjun Li and Yong Liu. PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism. Proc. Natl. Acad. Sci. USA. 108, 15852-15857 (2011).

1. Dongmei Wu, Yifu Qiu, Xiang Gao, Xiao-bing Yuan, Qiwei Zhai. Overexpression of SIRT1 in mouse forebrain impairs lipid/Glucose metabolism and motor function. Plos One, 6, e21759 (2011).